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Peng-Fei Ji

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Open access Oct 2026

TRPM7 promotes myocardial ischemia-reperfusion injury via CaMKII/DDX3X/NLRP3-mediated pyroptosis and m5C/ALYREF-dependent DDX3X stabilization

Myocardial ischemia-reperfusion injury (MIRI) poses a major clinical challenge. This study aimed to elucidate whether TRPM7 regulates cardiomyocyte pyroptosis during MIRI and its underlying mechanisms. We established both in vivo (I/R-injured mice) and in vitro (H/R-injured HL-1 cardiomyocytes) models and employed...

Jue-Sheng Yang, Shan Hu, Peng-Fei Ji et al. · 0 citations

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