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Author

Peng-Fei Liu

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Sep 2026

Kuwanon E sensitizes hepatocellular carcinoma cells to disulfidptosis via MTOR-mediated autophagy blockade.

Disulfidptosis, a recently identified form of regulated cell death driven by toxic intracellular disulfide accumulation and subsequent collapse of the actin cytoskeleton, represents a promising therapeutic vulnerability in hepatocellular carcinoma (HCC), particularly for tumors exhibiting metabolic reprogramming and re...

Xin-Yan Li, Liang-Wen Yan, Kai-Ling Hu et al. · 0 citations
Open access Aug 2026

NRF2-mediated ferroptosis suppression defines a cancer-specific vulnerability in tumors

This discovery fundamentally redefines the pathological role of NRF2 and positions NRF2 inhibition as a standalone, tumor-selective therapeutic strategy to eliminate Kras-driven malignancies by unleashing ferroptosis.

Dichun Huang, Mae Zhang, Ben N Stansfield et al. · 0 citations

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