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Peng-Fei Wang

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Open access Aug 2026

Spatial multi omic profiling maps hypoxia-driven pro-fibrotic SPP1+ macrophages underpinning immune escape and TACE resistance in hepatocellular carcinoma

An integrative spatial multi-omics strategy, combining bulk and single-cell RNA sequencing, subcellular-resolution spatial transcriptomics, and spatial proteomics on tissues from TACE-treated and treatment-naïve HCC patients, presents a potential therapeutic strategy to overcome TACE resistance and improve clinical out...

Fan-Sen Ji, Hao Chen, Boyang Wu et al. · Experimental Hematology & On... · 0 citations