Matrix Gla Protein is a novel regulator of TGFβ–dependent fibroblast activation and kidney fibrosis
It is shown that MGP deficiency attenuates renal fibrosis, suppresses fibroblast activation, and preserves kidney function following folic acid nephropathy and unilateral ureteral obstruction, supporting MGP as a potential fibroblast-associated target for future strategies aimed at limiting CKD progression.