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Author

Peng Hou

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Open access Aug 2026

The multimodal antidepressant vortioxetine exerts therapeutic effects in male mice which is associated with normalization of hippocampal SIK2/CRTC1-related signaling and require hippocampal CRTC1

It is demonstrated that vortioxetine’s antidepressant actions in male mice are associated with normalization of hippocampal SIK2/CRTC1-related signaling and require hippocampal CRTC1, providing a novel molecular mechanism underlying its multimodal efficacy.

Hui Xu, Hua Fan, E-Hui Ding et al. · 0 citations

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