Circular RNAs (circRNAs) have emerged as pivotal regulators in cancer biology, attributed to their stability, abundance, and tissue-specific expression. Dysregulation of the Hippo pathway is associated with various cancers, with circRNAs influencing its activity. These circRNAs exhibit aberrant expression in multiple c...
This review systematically elucidates the multidimensional regulatory mechanisms of m6A on ferroptosis regulatory factors, covering post-transcriptional modifications of the System Xc−/GSH/GPX4 antioxidant axis, iron metabolism-related proteins, and key enzymes of lipid peroxidation.
Yu-Shuo Duan, Zi-Yi Xu, Jia-Hao Liang et al.· Frontiers in Cell and Develo...· 0 citations
This study identified candidate biomarkers related to sorafenib treatment for HCC through computational analyses, experimentally validated the oncogenic function of RPS21, and predicted carbamazepine and diclofenac as potential combination therapies for precision treatment of HCC.
Mengru Zhan, Peng-Hui Li, Wan-Yi Wang et al.· Current Medicinal Chemistry· 0 citations
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