Open access
Oct 2026
Augmenting antitumor immunity in colon cancer via GSDMD-mediated pyroptosis induced by an attenuated Salmonella delivery system
As a major gastrointestinal malignancy, colon cancer (CC) demands more effective therapies. Gene therapy is an emerging promising strategy, and pyroptosis, a novel lytic cell death form, serves as a vital antitumor target, with Gasdermin D (GSDMD)—a key pore-forming protein in pyroptosis—showing anti-CC potential. We c...
Bing-Ran Han, X.-B. Si, Chuan-Jie Liu et al.
· Immunologic research · 0 citations