Author

Peng Lei

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Open access Aug 2026

A pro-natural product design strategy affords ester-based green fungicide candidates

Natural products (NPs) serve as both inspirations and resources for the discovery of bioactive compounds. However, their application in green agrochemical discovery faces limitations such as low activity, short duration of efficacy, potential toxicity and residue issues from structural modifications, and constraints in...

Peng Lei, H. Yuan, Xingxing Lu et al. · Science Advances · 0 citations

Aug 2026

Heterocycle-Substituted α-Methylene-γ-Butyrolactone Derivatives: Design, Synthesis, and Bioactivity against Phytopathogenic Fungi and Bacteria.

A series of 37 heterocycle-substituted α-methylene-γ-butyrolactone derivatives were designed and synthesized and exhibited the strongest antioomycete activity against P. capsici and Pseudomonas syringae pv actinidiae.

Deyou Yang, Heng Li, Yong-Xin Liang et al. · Journal of Agricultural and... · 0 citations

Aug 2026

Design, Synthesis, and Fungicidal Activity of Novel α-Methylene-γ-Butyrolactone Derivatives Bearing Benzofuran-2-yl Moiety.

A series of 30 novel α-methylene-γ-butyrolactone (MBL) derivatives were designed and synthesized. Bioassays revealed that several compounds exhibited potent fungicidal activities against Valsa mali, Rhizoctonia solani, and Phytophthora capsici. A25 showed the highest activity against V. mali (EC50 = 0.70 mg/L). Against...

Deyou Yang, Heng Li, Jiaying Xu et al. · Journal of Agricultural and... · 0 citations