Synergistic dual sensitizer integrated ZIF-8 nanoplatform for enhanced sonodynamic eradication of deep-seated drug-resistant biofilms.
Deep-seated biofilm infections caused by drug-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), remain a major clinical challenge due to restricted antibiotic penetration, hypoxic microenvironments, and intrinsic tolerance provided by biofilm structures. Sonodynamic therapy (SDT), whi...