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Review Oct 2026

Molecular mechanisms and therapeutic prospects of short-chain fatty acid-mediated regulation of rheumatoid arthritis via the gut-joint axis.

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and progressive joint destruction, and approximately 30-40% of patients respond inadequately to currently available disease-modifying antirheumatic drugs. Growing evidence suggests that immune abnormalities driving joint inflammation may arise...

Peng Qi, Xing-Wen Xie · 0 citations
Review Open access Oct 2026

Mechanisms and Application Strategies of Flavonoid Active Compounds in the Treatment of Osteoporosis-Osteoarthritis Comorbidity: Insights from Preclinical Studies

Abstract Osteoporosis (OP) and osteoarthritis (OA) are two prevalent age-related musculoskeletal disorders that frequently coexist in elderly populations, substantially complicating clinical diagnosis and treatment. In recent years, flavonoid active compounds have attracted increasing research interest for OP-OA comorb...

Xing-Wen Xie, Yan-Dong Liu, Yan-Jun Zhang et al. · 0 citations

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