Peng-Yu Xue

Immunotoxicological mechanism of a dual-targeted nanocomposite: Mitochondrial stress-driven cGAS-STING activation in lung cancer.

Lung cancer remains a leading cause of cancer mortality. We developed a dual-targeting nanocomposite FU@TPP/BSA@MnO/UA that induces mitochondrial dysfunction and activates the cGAS-STING pathway. The nanocomposite features a BSA-Mn2 + core, a FU@TPP shell for sequential, dual-stage targeting-first recognizing P-selecti...