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Author

Perminder S. Sachdev

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3 papers indexed here

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Review Aug 2026

Arterial spin labeling-derived cerebral blood flow as a translational biomarker and candidate surrogate endpoint for cognitive impairment.

PURPOSE OF REVIEW Arterial spin labeling (ASL) MRI noninvasively quantifies cerebral blood flow (CBF), but its role as a mechanistic biomarker and surrogate endpoint in trials of cognitive impairment remains undefined. This review evaluates evidence linking regional CBF to cognition across Alzheimer's disease, mild cog...

Satoshi Hosoki, P. Sachdev, M. Ihara · 0 citations
Open access Sep 2026

Long-PVSUNet: A Longitudinal Deep Learning Framework for Count-Oriented Perivascular Space Segmentation in Brain MRI.

Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast, and severe foreground-background imbalance make automated segmentation challenging. Existing methods are mainly cross-sectional and do not model temporal consistency, li...

S. Hayashi, Lei Fan, Jiyang Jiang et al. · 0 citations

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