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Petar-Bogomil Kanev

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Open access Aug 2026

DePARylation prevents DNA replication-driven PARP1 condensation

It is demonstrated that PARGi prolongs PARP1 residence at damaged chromatin in a manner mechanistically distinct from PARP-inhibitor-induced trapping, and dePARylation prevents the rapid nuclear extrusion of PARP1 upon S-phase entry.

Petar-Bogomil Kanev, Vanya Milanova, Preslava Berkova et al. · 0 citations

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