Open access
Sep 2026
Computational design of a versatile, zero-radius proximity labeling enzyme
FlexID is an engineered promiscuous ligase that catalyzes the rapid attachment of diverse small-molecule probes to proximal endogenous proteins and operates through a zero-radius, direct-contact mechanism, offering superior spatial precision compared to existing PL tools.
Shi-Zhong A. Dai, Peter E. Cavanagh, Albert Qiang et al.
· bioRxiv · 1 citation