Author

Peter Hoffmann

3 papers indexed here

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Oct 2026

Advancing Host Cell Protein Characterization in Monoclonal Antibody Therapeutics: A Nanoparticle-Enriched and High-Sensitivity Mass Spectrometry Approach

Host cell protein (HCP) characterization in monoclonal antibody (mAb) products is challenged by a large concentration gap between low-abundance HCPs and high-abundance mAb proteins. Advances in sample preparation, chromatography, and mass spectrometry techniques have aimed at either reducing this concentration imbala...

Abdulafeez Akinloye, Sri H. Ramarathinam, Parul Mittal et al. · Journal of Proteome Research · 0 citations

Open access Sep 2026

An integrated LC-MS/MS workflow for multi-matrix determination of glyphosate and aminomethylphosphonic acid for occupational exposure assessment.

Glyphosate, a widely used herbicide in agricultural and forestry settings, raises significant concerns regarding potential occupational exposure. However, comprehensive exposure assessment integrating biological and environmental monitoring remains limited, partly due to the lack of analytical workflows capable of supp...

Shu-Ping Qiang, Mahima Seeborun, A. Juhasz et al. · Journal of Chromatography A · 0 citations

Sep 2026

Middle-Down Mass Spectrometry Characterization of Monoclonal Antibody Enabled by Electron-Activated Dissociation on a Time-of-Flight Platform: A Case Study of Methionine Oxidation PTM Identification and Quantification

Characterizing post-translational modifications (PTMs) in monoclonal antibody products is critical for ensuring product quality attributes understanding and monitoring. While the bottom-up approach is widely adopted, it suffers from the loss of molecular connectivity and is susceptible to artifact generation. Convers...

Abdulafeez Akinloye, Leigh Donnellan, Parul Mittal et al. · Analytical Chemistry · 0 citations