Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice
Inhibition of orphan GPCR dimerization by small molecules is feasible and improves infection control and arterial hypertension.
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Inhibition of orphan GPCR dimerization by small molecules is feasible and improves infection control and arterial hypertension.
Using single-cell RNA sequencing, insight is provided into the cellular composition of a complex multicellular pathogen and how gene expression at single-cell resolution can serve as a resource for the identification of new drug targets is demonstrated.
TR-07 is established as the first selective, cell-active PRMT1 activator and underscores the therapeutic promise of this novel class of modulators.
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