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Author

Philip Hinchliffe

2 papers indexed here

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Open access Oct 2026

De Novo Design of Flavoproteins with Controlled Excited State Dynamics

Designing photochemical properties in proteins is a frontier challenge in biomolecular design, which, when realised, will open new avenues in catalysis and biomolecular electronics. Here we demonstrate an integrated computational design framework, supported by ultrafast spectroscopy, combining protein design, quantum m...

Ethan L. Bungay, Juno Underhill, Mei-Yue Liu et al. · 0 citations
Open access Oct 2026

Hydration Changes are Essential for Efficient Breakdown of Faropenem by the L1 Metallo-β-lactamase

Metallo-β-lactamases (MBLs) are key contributors to antimicrobial resistance (AMR). The L1 MBL, originally from Stenotrophomonas maltophilia, is a tetrameric, dizinc, subclass B3 MBL that efficiently hydrolyzes most β-lactam antibiotics and evades inhibitors that act on other MBLs. Using quantum mechanics/molecular m...

Papu Kalita, Carlos A. Ramos-Guzmán, Marko Hanževački et al. · 0 citations

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