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Philip J. Lupo

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Open access Sep 2026

Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate‐Induced Neurotoxicity and Ethnic Disparities

Methotrexate (MTX)‐induced neurotoxicity is a serious complication in pediatric acute lymphoblastic leukemia (ALL), with observed ethnic disparities in risk. To investigate the role of mitochondrial DNA (mtDNA) variation, we performed whole mtDNA sequencing in 94 children with ALL, including 62 Hispanic patients. We id...

Jing Han, Shahram Arsang-Jang, Paul L. Auer et al. · 0 citations

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