Philip Marx-Stoelting

Transcriptional Insights into Liver Toxicity from Mixture Effects of Pesticides and Natural Toxins: A case study of Propyzamide and Microcystins.

Humans are simultaneously exposed to multiple substances through diet and environmental sources, yet rigorously assessing the health risks of these combined exposures is challenging. New Approach Methodologies (NAMs) provide supporting tools, such as transcriptional analysis of cell models. Among relevant contaminants,...

GENOTOXICITY AND CARCINOGENICITY

Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study.

This work explores the applicability of new approach methodologies (NAMs) using a read-across approach to predict systemic toxicity with liver as the critical target organ, and derive a point of departurefor the target compound (TC) difenoconazole. Eight conazoles were used as source compounds (SCs), alongside metaboli...