Background Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applications. We leveraged the VA Million Veteran P...
Shuai Yuan, Michael G. Clark, G. Shakt et al.· Circulation· 0 citations
Type 2 diabetes mellitus (T2D) increases the risk of atherosclerotic diseases, including coronary artery disease (CAD), but decreases that for abdominal aortic aneurysm (AAA), forming an intriguing diabetes-atherosclerosis paradox. We investigate how genetic underpinnings and drug effects shape these complex relationsh...
Shu-Fen Zheng, Yonglin Wu, Ai-Jie Li et al.· Genomics, Proteomics & Bioin...· 0 citations
Background: Thoracic aortic aneurysms enlarge silently and can cause fatal aortic dissection without timely surgical repair, underscoring the need for improved approaches to identify individuals at high risk. Rare pathogenic variants in established heritable thoracic aortic disease (HTAD) genes explain only a subset of...
David R. Murdock, Pu-Jun Guan, Dong-Chuan Guo et al.· medRxiv· 0 citations
The observed genetic correlations are consistent with shared genetic liability between DED and chronic pain, autoimmune, and psychiatric traits, but do not establish causal direction.
Bryan R. Gorman, Jaxon J. Huang, Peter B. Barr et al.· EBioMedicine· 0 citations
Rare variants in MSH6 and BRCA2 are significantly associated with increased HCC risk, revealing a previously unconfirmed role for DNA repair genes in HCC susceptibility across ancestrally diverse populations and may inform genetic risk stratification and surveillance strategies.
A. Garófalo, Perapa Chotiprasidhi, Josephine P. Johnson et al.· JHEP Reports· 0 citations
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