Philipp Germer

S -Adenosyl- l -homocysteine Hydrolase Side Reactivity Enables Biocatalytic Access to 4′,5′-Dehydro Nucleosides as Nucleoside Drug Precursors

It is proposed that the SAHH- and SIHH-catalyzed dehydration reaction offers a straightforward strategy for the enzymatic synthesis of diverse 4′,5′-dehydro nucleosides as valuable precursors for chemical functionalization yielding 4′- or 5′-substituted nucleoside drug candidates.