Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer′s disease
Extracellular cold-inducible RNA-binding protein (eCIRP) is a crucial neuroinflammatory mediator in ischemic stroke and alcohol-induced memory impairment. We have recently discovered that amyloid-β causes microglia to release eCIRP, prompting us to investigate its role in Alzheimer’s disease (AD). We found that eCIRP l...