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Author

Philippe Marambaud

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Open access Sep 2026

Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer′s disease

Extracellular cold-inducible RNA-binding protein (eCIRP) is a crucial neuroinflammatory mediator in ischemic stroke and alcohol-induced memory impairment. We have recently discovered that amyloid-β causes microglia to release eCIRP, prompting us to investigate its role in Alzheimer’s disease (AD). We found that eCIRP l...

Archna Sharma, Dilara Aylar, D. Lapin et al. · 0 citations

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