Author

Piao-Piao Chen

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Nov 2026

Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples

Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based homogeneous electr...

Peng-Jun Jiang, Yue Wang, Ying Xiong et al. · ACS Nano · 0 citations

Oct 2026

Molecular filler-enhanced DNA nanomachines enable one-step multiplex quantification of ctDNA for mutation analysis and metastasis-associated assessment.

Detection of low-abundance biomarkers like circulating tumor DNA (ctDNA) remains challenging for molecular diagnosis and therapeutic management of cancer. Here, we developed a homogeneous electrochemical platform using metal ion-mediated DNA self-assembly enhanced by molecular fillers, enabling simultaneous, amplificat...

Yue Wang, Huan-Zuo Yang, Jian Li et al. · Science Bulletin · 0 citations

Oct 2026

Temperature-responsive PDDNFs@QDs integrating simplified isolation for efficient tumor-derived small extracellular vesicles analysis enables breast cancer diagnosis and subtyping.

Multiplexed small extracellular vesicles (sEVs) biomarker detection holds great promise for breast cancer diagnosis and subtyping; however, its clinical application is often hampered by the complex isolation and detection processes. Herein, we propose a temperature-responsive sensing platform (PDDNFs@QDs) utilizing pol...

Xiang-Yue Meng, Zhi-Hao Zhang, Peng-Jun Jiang et al. · Biosensors & bioelectronics · 0 citations