Introduction Prostate cancer (PCa) is one of the principal contributors to health burden in the aging male population. PCa develops through dysregulation of androgen receptor (AR) signaling pathways. Despite improvements in diagnostic techniques and interventions, no pharmacological measures with long term efficacy hav...
Avan Colah, C. Ezekiel, Sára Ferková et al.· Frontiers in Pharmacology· 0 citations
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder worldwide, yet therapeutic options remain limited. TMPRSS6, a liver serine protease best known for its role in iron homeostasis, has recently emerged as a potential therapeutic target for MASLD. However, the molecular...
Matthieu Lepage, A. Désilets, Gabriel Lemieux et al.· bioRxiv· 0 citations
This Primer outlines experimental and computational workflows tailored to peptide–GPCR interactions, including in silico peptide mining, deorphanization strategies, library-based screening platforms, modern pathway-resolved biosensor assays, and approaches for peptide stabilization and optimization strategies to addres...
J. Hermes, Marin Matic, H. Yeung et al.· Nature Reviews Methods Prime...· 0 citations
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