Pilar Ballesteros-Cuartero

Label Noise Limits TCR-pMHC Specificity Prediction: Improved Performance Through AlphaFold3-Based Structural Modeling and Data Denoising

T cell receptor (TCR) binding to peptides presented by major histocompatibility complex (MHC) molecules is a key step in T cell activation, and forms the basis of adaptive immunity. Predicting this specificity is therefore essential to developing effective TCR-based immunotherapies and vaccines. Despite its clinical re...