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Pim P. B. America

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Open access Sep 2026

RfaH licenses RNA polymerase for long-range transcription

Processivity is essential for gene expression: Escherichia coli RNA polymerase (RNAP) must transcribe 10+ kbp operons without failure, yet backtrack-induced long-lived pauses threaten premature termination. Gre factors stimulate transcript cleavage to rescue backtracked RNAP, whereas NusA and NusG, which bridge the exp...

Luca Buccolieri, Bing Wang, Pim P. B. America et al. · 0 citations

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