Pin-Jie Lu

Structural insights into a dual-substrate O-methyltransferase reveal the enzymatic mechanism of parallel paeonol biosynthesis

Paeonol, the medicinal indicator component of the traditional Chinese medicine ‘Mudanpi’, has an incompletely elucidated biosynthetic pathway, particularly its post-modification steps. Specifically, the post-modification processes involve 4′-O-methylation and 2′-hydroxylation, thus the formation can occur either sequen...