Abstract Pulmonary hypertension (PH) is a progressive vasculopathy characterized by pulmonary vascular remodeling, right ventricular maladaptation, and premature death. Exosomes, an endosome-derived subset of small extracellular vesicles, mediate intercellular communication through the transfer of selected RNAs, protei...
Meng-Nan Yuan, Ping Chen, Zi-Bo Zhan et al.· International Journal of Nan...· 0 citations
It is demonstrated that SDHB is down-regulated in fibrotic kidneys, and mechanistic insights into how TCA cycle disruptions and mtRNA leakage interactions drive renal inflammation are provided, suggesting SDHB as a potential therapeutic target for renal fibrosis.
Zi-Jing Zhu, Ping Chen, Hong-Xin Shu et al.· Metabolism: Clinical and Exp...· 0 citations
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