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Review Open access Oct 2026

Lipid droplet–mitochondria crosstalk in osteoarthritis: linking lipid routing to metabolic mismatch

Osteoarthritis (OA) is a whole-joint disease characterized by metabolic reprogramming beyond structural degeneration. Increasing evidence indicates that lipid droplets (LDs) regulate lipid storage, mobilization and intracellular lipid routing, while alterations in mitochondrial metabolism determine the capacity of chon...

Gang Meng, Rui-Jie Hou, Ping Dong et al. · 0 citations
Open access Oct 2026

Macrophage lipid metabolism and inflammasome activation in rheumatoid arthritis: emerging mechanisms and therapeutic implications

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, synovial hyperplasia, cartilage destruction, and bone erosion. Within the multicellular RA synovial network, macrophages act as important inflammatory effectors and metabolic sensors whose functional states are...

Hua Hao, Hong-Yu Zhao, Ping Dong et al. · 0 citations

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