Author

Ping He

2 papers indexed here

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Open access Sep 2026

R1-32-like public antibodies acquire tolerance to SARS-CoV-2 antigenic drift through somatic hypermutation.

R1-32-like public antibodies, characterized by shared IGHV1-69/IGLV1-40 usage, are elicited in more than 50% of individuals with COVID-19 and have been implicated in driving recurrent mutations at L452SARS2 and F490SARS2 within their convergent epitope in the SARS-CoV-2 spike receptor-binding domain. These mutations ef...

Chuan-Ying Niu, Xiao-Han Huang, Qi-Hong Yan et al. · PLoS Biology · 0 citations

Open access Sep 2026

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

ABSTRACT The rapid spread of immune‐evasive viral variants, exemplified by SARS‐CoV‐2, highlights the urgent need for broad‐spectrum coronavirus vaccines. Although multimeric display of the receptor‐binding domain (RBD) using exogenous scaffolds improve immune responses, such approaches may elicit off‐target immune res...

Xi-Kui Sun, Junhao Fan, Xiaolu Xie et al. · Advancement of science · 0 citations