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Case report Open access Sep 2026

A case report of delayed-diagnosed adult multisystem Langerhans cell histiocytosis with isolated MAP2K1 somatic mutation and systematic literature review

Numerous case reports regarding adult multisystem Langerhans cell histiocytosis (MS-LCH) have been published, yet the vast majority only describe single-organ involvement. Cases presenting sequential multi-organ lesions, clinical manifestations mimicking idiopathic hypophysitis and refractory gastritis, accompanied by...

Qi-Jian Zhang, Ping He, Yang Dong et al. · 0 citations

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