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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Pinghua Sun

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Open access Sep 2026

A bis(benzimidazolyl)-based anion transporter triggers chloride-initiated pyroptosis of MDA-MB-468 and 4T1 triple-negative breast cancer cells in vitro and in vivo.

As a highly heterogeneous subtype of breast cancers, triple-negative breast cancer (TNBC) poses significant therapeutic challenges. This study aims to systematically investigate the activity and mechanism of action of a benzimidazole-based anion transporter (i.e., compound 1) in treating TNBC both in vivo and in vitro....

Li Chen, Hao-Dong Yang, Jin-Hui Hu et al. · 0 citations
Sep 2026

Discovery of novel dual STAT3/TrxR1 inhibitors via pharmacophore fusion as potent lead compounds for colorectal cancer.

Constitutive activation of STAT3 and dysregulation of the thioredoxin reductase 1 (TrxR1) system are deeply implicated in the pathogenesis, progression, and drug resistance of colorectal cancer (CRC). Herein, guided by a pharmacophore fusion strategy, we rationally designed and synthesized a novel series of STAT3/TrxR1...

Yi-Gui Li, Rui Xu, Xin-Hua Xie et al. · 0 citations
Aug 2026

Structure-Based Discovery of JN210 as a Potent Dual DCN1/HDAC Inhibitor for the Treatment of Nonsmall Cell Lung Cancer.

A dual-targeting strategy aimed at simultaneously inhibiting the oncogenic protein-protein interaction between UBE2M and DCN1, which is critical for neddylation-dependent activation of cullin-RING ligases (CRLs) and histone deacetylase (HDAC) activity is developed.

Tao Zheng, Yi-Gui Li, Yun-Yuan Huang et al. · 0 citations

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