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Review Open access Aug 2026

NHE1 in Gastrointestinal Inflammation and Cancer: A Double-Edged Regulator.

PURPOSE Na+/H+ exchanger 1 (NHE1), encoded by SLC9A1, is a widely expressed plasma membrane transporter that exchanges intracellular H⁺ for extracellular Na⁺ and plays a central role in intracellular pH regulation. Beyond ion transport, NHE1 also functions as a membrane-associated regulatory platform involved in cell v...

Chang-Jian He, Tian He, Rui-Qing Tian et al. · 0 citations
Review Open access Sep 2026

SLC25 in intestinal inflammation: mechanisms, pathological roles, and therapeutic implications

Inflammatory bowel diseases (IBD) represent a spectrum of chronic gastrointestinal disorders fueled by a complex multifactorial interplay, where mitochondrial dysfunction has emerged as a critical contributor. The SLC25 family of mitochondrial transporters mediates the exchange of essential metabolites across the mitoc...

Juan Xu, Zan Zuo, Pei-Lin Wang et al. · 0 citations

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