NHE1 in Gastrointestinal Inflammation and Cancer: A Double-Edged Regulator.
PURPOSE Na+/H+ exchanger 1 (NHE1), encoded by SLC9A1, is a widely expressed plasma membrane transporter that exchanges intracellular H⁺ for extracellular Na⁺ and plays a central role in intracellular pH regulation. Beyond ion transport, NHE1 also functions as a membrane-associated regulatory platform involved in cell v...