Clockophagy in Alzheimer’s Disease: An Emerging Hypothesis Linking Circadian Dysfunction to Ferroptotic Vulnerability
Alzheimer’s disease (AD) is frequently associated with sleep disturbances and circadian dysfunction, which may precede or accompany clinical manifestations and have been associated with amyloid-β (Aβ) pathology, tau abnormalities, oxidative stress, lipid peroxidation, and neuronal vulnerability. Increasing evidence sug...