Closing the CO2-to-glycolic acid loop through efficient methanol bioconversion enabled by cofactor-neutral metabolic rewiring.
Chemo-biological valorization of CO2 into value-added chemicals, such as the biodegradable plastic monomer glycolic acid (GA), represents a promising frontier in sustainable manufacturing. However, the realization of this synergistic loop is hindered by the low carbon efficiency of C1 bioconversion. Herein, we address...