Open access
Sep 2026
Genetic mechanisms of mitotic error in 840,853 blood genomes
Mosaic aneuploidies in leukocytes are commonly detectable in aging individuals. Here, we studied inherited genetic influences on susceptibility to such aneuploidies by precisely quantifying chromosomal ploidy from whole-genome sequencing read-depth in 840,853 individuals. This approach revealed autosomal gains in ~70,0...
Yao-Qiong Si, Nolan Kamitaki, D. Tang et al.
· medRxiv · 0 citations