DeepPH is a structure-aware framework that models enzyme optimal pH as an interval regression problem to capture inherent uncertainty and outperforms existing methods under both standard and interval-aware evaluations and generalizes well to extreme-length sequences.
Wei Wang, Po-Yu Liang, Jun Bai· IEEE journal of biomedical a...· 0 citations
BACKGROUND
Diffuse middle glioma (DMG or DIPG) is a fatal pediatric brain tumor. Although chimeric antigen receptor (CAR) T-cell therapy shows promise, clinical outcomes remain inconsistent due to premature exhaustion, underscoring a critical need to improve CAR-T persistence. A major barrier to CAR-T efficacy is antig...
PepEDiff is presented, a novel peptide binder generator that designs binding sequences given a receptor protein and the target pocket residues that outperforms state-of-the-art approaches across benchmark tests and in the TIGIT case study, demonstrating its potential as a general, structure-free framework for zero-shot...
Po-Yu Liang, Tibo Duran, Jun Bai· ACM International Conference...· 1 citation
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