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Author

Po-Yuan Chen

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Oct 2026

TESERA: morphologic subtyping and prognostic stratification of hepatocellular carcinoma from H&E whole-slide images.

These findings position routine histology as a low-cost, widely available substrate for biology-aware risk stratification in HCC and unifies morphologically derived metabolism-versus-proliferation subtypes with an externally validated, prognostic morphologic index competitive with existing clinical and molecular marker...

Tyler M. Yasaka, Shaila Afrin, Po-Yuan Chen et al. · 0 citations
Open access Aug 2026

Multimodal contrastive learning for integrating molecular representations and cellular phenotypes in drug-target interaction prediction

A two-stage contrastive learning framework integrating drug structures, protein sequences, and Cell Painting morphological profiles into a unified embedding space, which reveals pathway-specific morphological signatures associated with drug targets, providing biologically interpretable insights into drug mechanisms.

Ying-Ju Lai, Tianyuzhou Liang, Po-Yuan Chen et al. · 0 citations

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