Poy Theprungsirikul

Proteostasis as a Therapeutic Backbone: Proteasome Inhibitors and Emerging Regimens

Multiple myeloma cells are uniquely dependent on proteostasis due to their exceptionally high immunoglobulin synthesis and protein turnover, rendering them hypersensitive to disruptions in protein degradation. Proteasome inhibitors targeting the 20 S catalytic core exploit this vulnerability and remain a therapeutic co...