Author

Prajakta Warang

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Jul 2026

Immune checkpoint blockade enhances CD4 effector function and enables control of persistent viral infection 2310195

A previously unrecognized and novel, IL-27—independent CD4+ T cell axis through which PD-1 checkpoint blockade restores antiviral immunity during persistent viral infection is revealed, redefining the mechanistic landscape of checkpoint immunotherapy.

Prajakta Warang, J. Teijaro · Journal of Immunology · 0 citations

Open access Jul 2026

Immune checkpoint blockade enhances CD4 effector function to control persistent viral infection 2267612

It is demonstrated that PD-1 inhibition enhances CD4+ T cell function, specifically through increased IL-21 production from T follicular helper (Tfh) cells which promotes both humoral and cytotoxic antiviral responses.

Prajakta Warang, J. Teijaro · Journal of Immunology · 0 citations