Review
Aug 2026
Targeting BRAF dimerization in cancer: structural insights and therapeutic strategies beyond monomer inhibition.
The mitogen-activated protein kinase (MAPK) signaling pathway is a central oncogenic signaling axis, with BRAF functioning as a critical regulatory node. The discovery of oncogenic BRAF mutations, most notably BRAFV600E, enabled the development of targeted therapies that significantly improved clinical outcomes in seve...
Jayhind Bharti, Priyadharshini Gogu, Dhanashree N. Sarwan et al.
· Biochemical Pharmacology · 0 citations