Open access
Sep 2026
Mechanical Quantification of Molecular Interactions Reveals Spatiotemporal Fluctuations on the Cell Surface
The cell membrane hosts initial interactions between receptors and ligands for subsequent cellular functions. However, how the membrane spatiotemporally regulates binding mechanics in living cells remains unclear. Using magnetic tweezers, we developed a single-molecule platform to reveal that dissociation forces of i...
Sajan Shakya, Zhi-Lei Zhang, Payton Ciolli et al.
· Journal of the American Chem... · 0 citations