Dihydropyrimidines as Multifaceted Scaffolds: A Comprehensive Review of Synthetic Approaches and Biological Significance.
Dihydropyrimidines (DHPMs) are an important class of heterocyclic compounds with broad pharmacological and therapeutic potential. Among the various synthetic routes for assembling the DHPM frame, the classical Biginelli reaction remains the most effective and widely used method due to its convenient one-pot procedure....