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Author

Priyajit Kaur

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Aug 2026

Discovery of SARS-CoV-2 PLpro covalent inhibitors enabled by a novel reversible covalent chloroalkyne warhead.

These findings establish chloroalkyne as a promising target-directed reversible covalent warhead for PLpro inhibition and provide in vivo proof-of-concept for this chemistry in antiviral drug discovery, with potential for broader application to other cysteine proteases.

Divakar Indukuri, J. G. Achi, Boopathi Sownthirarajan et al. · 0 citations

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