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Author

Purnima Khandelwal

2 papers indexed here

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Aug 2026

Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.

BMS-986449 is an orally available degrader that demonstrates single-agent growth inhibition of syngeneic MC38 tumors implanted in humanized Cereblon (CRBN) knock-in mice and establishes BMS-986449 as a promising clinical candidate for cancer immunotherapy.

E. Cherney, S. Nair, Suresh Babu Viswa Krishna Penmetsa et al. · 1 citation
Sep 2026

Automated High-Throughput Ligand-Detected NMR for Medicinal Chemistry Hit Triage and Binding Assessment.

A fully automated, ligand-detected high-throughput NMR (HT-NMR) workflow, applicable to aromatic-ring-containing compounds common to high throughput screening libraries, which delivers compound triage and binding assessment.

Bradley Falk, Luciano Mueller, E. Braunstein et al. · 0 citations

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