Pharmacokinetics of Vancomycin and Dosing Regimen in Critically Ill Patients With Sepsis or Septic Shock: A Narrative Review
Background: Vancomycin is a drug of choice in Methicillin-resistant Staphylococcus aureus (MRSA) infection. The AUC24/MIC of 400-600 μg·h/mL is recommended to achieve therapeutic outcome and prevent nephrotoxicity. In critically ill patients with sepsis/septic shock, various physiological changes may impact vancomycin...