Q. Le Grand

Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Traditional MRI-markers of cSVD are mainly detectable in older adults, but diffusion MRI (dMRI) measures of white matter microstructure can capture changes predisposing to cSVD earlier in life. In this study, we conducted large genomics and...

Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease

A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility