Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is unclear. Here, we show that elevated serum hepcidin is associated with reduced survival and decreased intratumoral CD8+ T...
J. Schoenfeld, Jahi J. Noel, Christopher S. McGinnis et al.· bioRxiv· 0 citations
Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.
Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al.· Nature· 0 citations
An ensemble approach (enFoldX) that leverages structure prediction models such as AlphaFold3 to build sensitive binding predictors and outperforms the current co-folding methods which rely on predictions from the single top ranked structure.
O. Lyudovyk, Jonathan A. Levine, M. Pathil et al.· Clinical Cancer Research· 0 citations
An ensemble approach (enFoldX) that leverages structure prediction models such as AlphaFold3 to build sensitive binding predictors and outperforms the current co-folding methods which rely on predictions from the single top ranked structure.
O. Lyudovyk, Jonathan A. Levine, M. Pathil et al.· Clinical Cancer Research· 0 citations
Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC). Accurate prediction of TCR:pMHC binding pairs from sequence data remains a longstanding challenge in computational immunology, limiting the development of precision immunotherapies like ca...
O. Lyudovyk, JA Levine, M. Pathil et al.· bioRxiv· 1 citation
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