Author

Q. Ran

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Open access Oct 2026

Macrophage- or neutrophil-expressed UPP1 drives tumor growth and immune suppression in the tumor microenvironment

Uridine phosphorylase 1 (UPP1) has recently emerged as a metabolic regulator with critical roles in tumor cell biology. However, its expression pattern and functional significance in nonmalignant components of the tumor microenvironment (TME) remain largely unexplored. Here, we performed a comprehensive pan-cancer sing...

Yin Li, Qin Ran, An-Ying Xiong et al. · Science Advances · 0 citations

Review Open access Sep 2026

Trained immunity and related memory responses in lung health and disease

Immune memory has long been attributed to adaptive immunity, but trained immunity has broadened this view by showing that innate immune cells can retain altered function after prior stimulation and mount an enhanced response upon rechallenge. In the lung, prior local exposures can alter resident alveolar macrophages, w...

Xin-Yu Sun, Dan Zhao, Lei Zhang et al. · Frontiers in Immunology · 0 citations