Author

Q. Teo

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Open access Sep 2026

Epistasis and pleiotropy constrain the evolution of cross-reactive breadth in a broadly neutralizing influenza antibody

The findings provide a mechanistic explanation for the scarcity of HA stem bnAbs with cross-reactivity against both influenza A and B viruses, and have important implications for developing broadly protective influenza vaccines.

Katrine E. Dailey, Yi-Quan Wang, Q. Teo et al. · PLoS Biology · 0 citations

Open access Jul 2026

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

The structural basis by which specific mutations enhance cross‐variant recognition of SARS‐CoV‐2 is defined, highlighting the underappreciated breadth encoded within the naïve B‐cell repertoire and providing a conceptual framework for engineering and eliciting antibody responses resilient to future antigenic drift.

Huibin Lv, Ziqi Feng, Q. Teo et al. · Advancement of science · 0 citations